• During the past three decades platinum based DNA alkylating

  2019-09-04

  

  During the past three decades, platinum-based DNA-alkylating agents have been employed in the treatment of various cancers [14]. Oxaliplatin is currently used as a first-line treatment for colorectal cancer (CRC) [15]. Unfortunately, a large portion of CRC patients receiving oxaliplatin-based chemot

• ASC was reported as a potent antiviral and antifungal

  2019-09-04

  

  ASC was reported as a potent antiviral and antifungal agent, and its derivatives could modulate a variety of physiological activities, such as anti-tumor, anti-metastatic, and anti-diabetic activities in animals. Mie Tsuruga et al. found that 4-o-methylascochlorin had immunosuppressive activity, but

• With the recent expanse of technology to evaluate synthetic

  2019-09-04

  

  With the recent expanse of technology to evaluate synthetic lethality, new combinations with DHODH inhibitors may be uncovered (O\'Neil, Bailey, & Hieter, 2017). Many oncogenic backgrounds share synthetic lethality with DHODH. Cells with mutant PTEN have increased glutamine metabolism and are sensit

• Dgat mice however had less adipose tissue as reflected

  2019-09-04

  

  Dgat−/− mice, however, had less adipose tissue, as reflected by lower total fat pad weights and body triglyceride content. Because of these findings, we hypothesized that, although Dgat−/− mice could make triglycerides through non-DGAT pathway(s), their triglyceride synthesis capacity might not be e

• We had earlier reported that

  2019-09-04

  

  We had earlier reported that collagen fibers with intact native banded structure were occasionally observed in the kinase-deficient, membrane-anchored DDR2 ECD (DDR2/-KD) samples; however, in our DDR1/ECD and DDR2/ECD samples, observation of native banded structure of collagen was far more infrequen

• Cytochromes P CYP are a superfamily of hemoproteins

  2019-09-04

  

  Cytochromes P450 (CYP 450) are a superfamily of hemoproteins containing a heme cofactor, which are widely distributed in animals, plants and microbes (Hannemann et al., 2007). CYP450 exhibits a variety of biological functions including biotransformation of drugs, detoxification of endogenous and xen

• hydroxychloroquine sulfate Introduction Cytochrome P CYP A i

  2019-09-04

  

  Introduction Cytochrome P450 (CYP)3A is the most important enzyme involved in the metabolism of 30–40% of currently prescribed drugs [1]. The hydroxychloroquine sulfate level and activity of CYP3A show large intra- and inter-individual variability, which contributes to unpredictable drug response a

• It is now known that

  2019-09-04

  

  It is now known that cholinergic signaling plays a vital role in controlling many peripheral functions including skeletal and smooth muscle contraction, autonomic postganglionic neuron activation, parasympathetic end-organ activation (e.g., salivary, lacrimal and bronchial glands), regulation of car

• The CLC proteins in Arabidopsis have

  2019-09-04

  

  The CLC proteins in Arabidopsis have been studied in some detail, and a total of seven genes (named AtCLCa-AtCLCg) have been identified (Lv et al., 2009). It is interesting that AtCLCa-AtCLCd and AtCLCg define a distinct phylogenetic branch that is closely related to eukaryotic CLCs, while the other

• Cell migration and invasion are central processes in the dev

  2019-09-03

  

  Cell migration and invasion are central processes in the development and metastasis of cancer. The regulation of cell migration by DDR1 has been reported in many types of cancer cell lines; however, conflicting results have been reported regarding the inhibitory as well as promotive effects of DDR1

• Findings from this study also indicate

  2019-09-03

  

  Findings from this study also indicate that DAPK regulated BimEL expression during OGD as DAPK shRNA transfection inhibited OGD-induced increase of BimEL. A previous study shows that Bim is found in ER compartment in stressed Cy3-dUTP but not in normal cells, indicating translocation of Bim during E

• In addition we investigated if the previously reported

  2019-09-03

  

  In addition, we investigated if the previously reported papain inhibitor can inhibit rhodesain, and found that it was not active at inhibiting rhodesain. The vinyl sulfone analogue of () was then synthesized and tested, and it was also inactive towards rhodesain. We then determined the time depend

• This research was funded by grants from

  2019-09-03

  

  This research was funded by grants from the National Institute on Aging (2R01AG017141-06A2) and the National Center for Complementary and Alternative Medicine (P01AT002034). We also acknowledge the facilities service core of the Environmental Health Science Center (NIEHS ES00240). The authors would

• Organ fibrosis is thought to be initiated

  2019-09-03

  

  Organ fibrosis is thought to be initiated by repeated or chronic epithelial injury. The current belief is that damaged epithelial gabazine induce an aberrant and unresolved wound repair process by activating fibroblasts via various profibrotic cues. Upon injury, epithelial cells activate the profib

• CD is a key co stimulation surface marker

  2019-09-03

  

  CD28 is a key co-stimulation surface marker that can be detected in all peripheral T cdk7 in newborns, and the proportion of CD28bearing T cells reduces progressively with age [reviewed by (Fagnoni et al., 1996; Weng et al., 2009)]. Therefore, CD28nullCD8+ T cells are one of the most acknowledged c

15411 records 925/1028 page Previous Next First page 上5页 921922923924925 下5页 Last page