• What are the molecular signals

  2020-07-31

  

  What are the molecular signals that guide Tfh cells as they navigate around the lymph node in the course of the immune response? It was recently reported that Tfh cells inside GCs have high expression of SIPR2, which acts to repel them from the S1P-rich lymph in the SCS and promote their retention i

• sbha br STAR Methods br Acknowledgments We

  2020-07-31

  

  STAR★Methods Acknowledgments We thank A. Rongvaux, L. Evangelisti, J. Stein, C. Hughes, and L. Borelli for help with generating Gpr183−/− mice. We also thank L. Zenewicz for providing cDNA and G. Eberl (Pasteur Institute) for providing Rorc(γt) transgenic mice. R.A.F. is an investigator of the

• How does APC C recognize its substrates

  2020-07-31

  

  How does APC/C recognize its substrates and catalyze their ubiquitylation? How are the outcomes and timing of these activities regulated? These questions have driven a decade of structural studies that begin to explain how APC/C interacts with coactivators, substrates, and E2s, and how these interac

• It was thus found that E

  2020-07-31

  

  It was thus found that E1 plays an important role in G. intestinalis biology. Inhibiting E1 expression by RNA antisense in trophozoites was lethal while E1 overexpression induced a five-fold increase in cyst formation during encystation. The changes in E1 location during this process and its localiz

• The Nile tilapia Oreochromis niloticus is an important farme

  2020-07-31

  

  The Nile tilapia (Oreochromis niloticus) is an important farmed fish with an XX/XY sex-determining system. The availability of the whole genome sequence of tilapia and tissue transcriptomes (Brawand et al., 2014), together with its gonadal transcriptomes at different developmental stages (Tao et al.

• br Results br Discussion In

  2020-07-31

  

  Results Discussion In this study, we show that hepatic lineages are reversible between adult MSCs and hepatocytes. Such reversibility is regulated by the TGFβ1-DNMT axis. To the best of our knowledge, this is also the demonstration that hepatocytes can be converted into multi-potent MLCs witho

• Small angle X ray scattering SAXS

  2020-07-31

  

  Small angle X-ray scattering (SAXS). Synchrotron SAXS measurements (I(s) vs s, where s = 4πsinθ/λ; 2θ is the scattering angle and λ = 0.125 nm) were performed at the EMBL-P12 bioSAXS beam line at the PETRA III storage ring (DESY, Hamburg) as described in Ref. [26] under continuous-flow batch mode op

• br Phenotypic responses alkylation induced cell death

  2020-07-31

  

  Phenotypic responses: alkylation-induced cell death and mutagenesis E. coli alkB mutants were isolated in a screen for strains specifically sensitive to the cytotoxicity of MMS but not UV-irradiation. This was the first indication that the AlkB protein is a primary cellular defence against alkyla

• The nucleus has a phosphatidylinositol

  2020-07-31

  

  The nucleus has a phosphatidylinositol cycle that is regulated separately from the plasma membrane PI signalling [74]. Like its extranuclear counterpart, nuclear DAG signalling appears to be compartmentalized. Indeed, D\'Santos et al. [75] demonstrated independently fluctuating pools of nuclear DAG

• br Methods of calculations The results of this

  2020-07-31

  

  Methods of calculations The results of this work have been compared with those recently reported in the Ref. [5]; therefore all calculations and molecular simulations have been performed using the same techniques previously used. Experimental section Results and discussion We recently repo

• Sulphadoxine pyrimethamine SP is an anti

  2020-07-31

  

  Sulphadoxine-pyrimethamine (SP) is an anti-malarial combination drug that was once commonly used, but that has been abandoned as first-line treatment due to increasing resistance in malaria parasites. At present, SP is used for intermittent preventive treatment with SP during pregnancy (IPTp-SP) in

• br Funding sources br Introduction Psychiatric comorbidities

  2020-07-31

  

  Funding sources Introduction Psychiatric comorbidities affect up to 70% of people with pharmacoresistant epilepsy and significantly impact quality of life [1]. Psychiatric comorbidities in epilepsy have been thought to be due to psychosocial stress. However, recent evidence suggests a more com

• br Acknowledgement This research was

  2020-07-30

  

  Acknowledgement This research was partly funded by the National Science Foundation\'s Long-Term Ecological Research Program (DEB 1027253), by the National Science Foundation\'s Geobiology and Low Temperature Geochemistry Program (Award no. 1630399), by the Department of Energy Great Lakes Bioener

• Although several studies have reported that Mn could

  2020-07-30

  

  Although several studies have reported that Mn could induce ER stress (Chun et al., 2001, Yoon et al., 2011a), little data in detail exist on the effects of Mn on the three UPR signal pathways, information that is critical for more fully evaluating the Mn-induced neurotoxicity. Therefore, to explore

• In conclusion we provide convincing

  2020-07-30

  

  In conclusion, we provide convincing evidence that the PRRSV-induced SGs are indeed bona fide SGs. While we determined that mRNA is present in the PRRSV-induced SGs, we did not distinguish its origin. Future studies will need to determine whether the mRNA stored in PRRSV-induced SGs is of cellular o

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