• Primary renal PNET was first

  2021-06-09

  

  Primary renal PNET was first reported by Seemayer et al in 1975. The possible etiology of rPNET is based on the theory of neural cell intussusception in the kidney during development that initiates the tumorigenesis. rPNET most commonly affects young adults, with a mean age of 30.4 years and male pr

• p and p which are downstream of

  2021-06-09

  

  p21 and p16, which are downstream of pAkt and pERK1/2, are tumor suppressors which induce cell senescence and HO-3867 arrest [[56], [57], [58]]. Inhibitors of pAkt or pERK1/2 can activate p21 and p16 and promote cell senescence and cell cycle arrest [11,12,[59], [60], [61]]. It is well known that p

• br Acknowledgments br Significance The mechanisms underlying

  2021-06-09

  

  Acknowledgments Significance The mechanisms underlying the adverse effects of Epo-stimulating agents on the reduced survival of cancer patients are not well understood. Here, we identified EphB4 as an alternative Epo receptor, which triggers Src/Stat3 signaling via EphB4. We also showed that r

• Multiple technologies exist for analyzing the contents of

  2021-06-09

  

  Multiple technologies exist for analyzing the contents of single cells, including single-cell DNA sequencing, RNA expression analysis, and protein level and activity measurements (Hu et al., 2018; Narrandes & Xu, 2018; Ortega et al., 2017; Wang & Navin, 2015). Single-cell DNA sequencing is generally

• On the opposite side sPLA X has also

  2021-06-09

  

  On the opposite side, sPLA2-X has also been implicated in the pathology of cancer [167,168]. Human sPLA2-X induces lipid droplet formation in Ras-driven MDA-MB-231 triple-negative breast cancer TC-E 5003 receptor and promotes their survival during nutrient stress. It acts through the products of it

• In human neuroblastoma SH SY Y cells and in

  2021-06-09

  

  In human neuroblastoma SH-SY5Y MTT and in lymphoma Jurkat cells, Yamanaka et al. [56] showed that exogenously added 24(S)-hydroxycholesterol could be efficiently esterified by ACAT1. These results suggest that both ACAT1 and ACAT2 can control the oxysterol levels by directly esterifying them, in a

• br Materials and methods br Results

  2021-06-09

  

  Materials and methods Results Discussion Although some conditioning therapies have provided satisfactory clinical outcomes, mammalian species have little or no ability to replace injured cardiac tissue [34]. Therefore, therapeutic strategies based on the prevention, rather than treatment af

• The glycolytic pathway is a catabolic route that ends with

  2021-06-09

  

  The glycolytic pathway is a catabolic route that ends with the synthesis of pyruvate (Pyr). In Arabidopsis embryos, the conversion of phosphoenolpyruvate (PEP) to Pyr, catalyzed by pyruvate kinase (PK), is mainly located in the plastids [10], [11]. The preceding reaction is catalyzed by enolase (ENO

• aminoisobutyric acid BAIBA is a natural catabolite of the

  2021-06-08

  

  β-aminoisobutyric m-Chlorophenylbiguanide hydrochloride sale (BAIBA) is a natural catabolite of the branched-chain amino acid thymine. BAIBA was recently found to reduce inflammation in skeletal muscle via the AMP-activated protein kinase (AMPK)-peroxisome proliferator-activated receptor (PPAR)δ sig

• Temozolomide In the present study we implemented the dendrit

  2021-06-08

  

  In the present study, we implemented the dendritic RCA-induced formation of amplifying DNAzyme catalytic labels strategy for sensitive and accurate assay of MTase activity and the detection of DNA methylation. In comparison with the traditional RCA process, the proposed strategy achieved high amplif

• DNA methylation assay To test the biological activity of pur

  2021-06-08

  

  DNA methylation assay. To test the biological activity of purified A1S_0222, a methylation assay was performed using the Int1 DNA. As an alternative DNA substrate, Seq3 (located in gene A1S_0965 of A. baumannii ATCC 17978) was amplified from Acinetobacter baumannii 29D2 using the oligonucleotides Se

• Because aspirin and ibuprofen are NSAIDs

  2021-06-08

  

  Because aspirin and ibuprofen are NSAIDs, both cause a variety of adverse effects, including stomach ulcers, stomach bleeding, coagulation disorders, ephrin receptor and cerebral microbleeds [13]. Moreover, both cause liver damage [10]. Laster [14] reported a patient with pericarditis treated with

• As described above we designed and

  2021-06-08

  

  As described above, we designed and synthesized a new 1,4-di-substituted isoquinoline lead compound, and was identified as a ligand with moderate potency for the CRTH2 receptor. We initially we examined the effects of the steric factor of R group on the CRTH2 binding potency (). When the methyl gro

• Both anxiogenic and antinociceptive effects produced by CRF

  2021-06-08

  

  Both anxiogenic and antinociceptive effects produced by CRF seem to be selective for the CRF1 receptor, since intra-dPAG microinjection of ASV 30, a CRF2 receptor antagonist, altered neither the anxiety nor the antinociception response. Intra-dPAG ASV 30 was also unable to prevent the anxiogenic (ob

• Taking into account that Gr

  2021-06-08

  

  Taking into account that Gr dysfunction is involved in the molecular mechanisms underlying HPA axis disorder (Li et al., 2017b) and Gr activity has been reported to be lowered in patients with severe mood disorders (Rush et al. 1996) and in adult rats (Green et al. 2016), PFOS could alter HPA axis a

15836 records 618/1056 page Previous Next First page 上5页 616617618619620 下5页 Last page