• The SLC A mutations identified in both families appear

  2022-01-04

  

  The SLC45A1 mutations identified in both families appear to be hypomorphic given that they resulted in a reduction but not abolition of intracellular glucose transport by SLC45A1 in our in vitro assay. It is tempting to speculate that recessive mutations causing a more severe dysfunction of the tran

• br Summary The presented results of the

  2022-01-04

  

  Summary The presented results of the analysis of the unfolding of G-quadruplex and i-motif, which may appear within the telomeric DNA region, led to several important conclusions. Namely, determination of the work necessary to unfold of these structures, in biased molecular dynamics involving ste

• Recent evidence indicates that prolonged vasoconstriction

  2022-01-04

  

  Recent evidence indicates that prolonged vasoconstriction of conductance and resistance arteries involves VSMCs Clotrimazole receptor polymerization, through activation of small GTPases [4] and a subsequently transition to a more solid rheology [5]. Actin polymerization occurs in two steps, nucleat

• The improved glucose tolerance of

  2022-01-04

  

  The improved glucose tolerance of Ffar1R258W/R258W mice on HFD was unexpected. In combination with similar fasting blood glucose levels, the significant lower fasting plasma insulin of mutant mice compared to wild-type mice is indicative of improved insulin sensitivity. However, peripheral insulin r

• br Experimental br Results and discussion First of

  2022-01-03

  

  Experimental Results and discussion First of all we had to choose suitable electrolyte´s system. We utilized advantageously the composition of the background electrolyte for biogenic amines separation published in our work [13] to which we adapted the leading and terminating electrolytes. With

• Despite the rapid development of synthetic ligands

  2022-01-03

  

  Despite the rapid development of synthetic ligands, the endogenous ligands of GPR109A, GPR109B and GPR81 remained elusive until recently. This is probably the result of their relatively low potencies and their metabolite character (Table 1). Traditionally, agonists of GPCRs were believed to belong t

• br Conclusion br Author statement br Acknowledgments br

  2022-01-03

  

  Conclusion Author statement Acknowledgments Introduction The hypothalamic-pituitary-gonadal (HPG) axis is an important neurohormone network for vertebrates that regulates their gonadal development and maturation, guarantees their pubertal development and maintains their normal reproducti

• The main results whose proofs depend

  2022-01-03

  

  The main results, whose proofs depend on the explicit calculation of , include To set our work into the historical context, we note that the transporter category algebras are skew group algebras, and thus are fully group-graded algebras. This work is partially motivated by the papers on fully group

• Percentage contribution to free glutamate intake was

  2022-01-03

  

  Percentage contribution to free glutamate intake was also calculated at the food item level. A list of the top 30 foods for children and adults are presented separately in Table 2. The top 4 foods included in this list are watermelon, raw; tomato catsup; tomatoes, raw; and roll, white, soft. These a

• The presence of ghrelin s mRNA in

  2022-01-03

  

  The presence of ghrelin's mRNA in the eye and the presence of ghrelin in the aqueous humor, along with a decrease of its levels in glaucoma, suggest a local role for this peptide in the ocular tissue [8], [16], [18]. There is no available data regarding the presence of GHSR-1 in the anterior segment

• In conclusion the data reported in this

  2022-01-03

  

  In conclusion, the data reported in this study have demonstrated an important role for FAAH substrates in the cholecystokinin receptor in the modulation of TLR4-induced neuroinflammatory and associated anhedonic responses, but not acute sickness behaviour. Such potent neuroimmunomodulatory effects

• br Rho family GTPases are molecular switches most

  2021-12-31

  

  Rho-family GTPases are molecular switches; most which cycle from an ‘on’ GTP bound state to an ‘off’ GDP bound state, driven by GEFs (guanine nucleotide exchange factors) and GAPs (GTPase-activating proteins) respectively. Association with lipid membranes through a lipid (farnesyl or geranylgerany

• br Materials and methods br Results br Discussion

  2021-12-31

  

  Materials and methods Results Discussion Although there is general agreement that GPR109A has anti-lipolytic activity and that the NEFA reduction in response to nicotinic (+)-MK 801 is mediated by GPR109A, whether GPR109A activation has any impact on plasma TG levels is unclear. Since the

• GPR detection by reverse transcription polymerase

  2021-12-31

  

  GPR35 detection by reverse transcription-polymerase chain reaction (RT-PCR). Total RNA of cultured DRG neurons was extracted using the RNAqueous kit (Ambion). Complementary DNA (cDNA) was synthesized from 1μg of isolated total RNA with SuperScript III reverse transcriptase (Invitrogen). An aliquot o

• Due to the therapeutic potential of GlyT

  2021-12-31

  

  Due to the therapeutic potential of GlyT1 inhibitors, numerous drug screening campaigns have been started - and are still going on - which aimed at the identification of compounds with biological activity at or affinity for this drug target. For characterization of biological activity at GlyT1, tran

15782 records 493/1053 page Previous Next First page 上5页 491492493494495 下5页 Last page