Taken together our findings suggest that

2018-10-20

Taken together, our findings suggest that in PD, the heterozygous GBA-N370S mutation leads to the misprocessing of GCase, ER stress upregulation, and autophagic/lysosomal dysfunction in dopaminergic neurons. We propose that this combination of disturbances impairs protein homeostasis in dopamine neu

Using both standard RNA seq

2018-10-20

Using both standard RNA-seq and RNA-seq lipoxygenase analysis, we identified UPF1-regulated transcripts that are good candidates to be direct NMD targets in hESCs. There was considerable overlap between these candidate NMD target transcripts expressed in hESCs with previously identified high-confid

Finally we tested whether the B cell differentiation defect

2018-10-20

Finally, we tested whether the B cell differentiation defect in the OsxCre;iDTR mutants could be rescued in vivo by intravenous administration of recombinant IL-7 and IGF-1. Both controls and mutants were subjected to daily injections of DT, DT + IL-7, or DT + IGF-1 for 12 days. At the end of the re

Remarkably the changes described suggest

2018-10-20

Remarkably, the changes described suggest that in vivo reprogramming-induced dedifferentiation renders a change at telomeres toward a more “juvenile” state, which in turn resembles that of ESCs and adult stem purchase GW788388 (see Figure 7). In this regard, we have previously described telomerase-

Hello world!

2018-07-29